Benzenesulfonyl chloride → HCID 68677022, compound

Participants

Reaction Steps

A solution of 50 mg of 8-(2-amino-ethylamino)-6-tert-butyl-2H-[1,2,4]triazolo[4,3-a]pyrazin-3-one, 97 mg of phenylsulfonyl chloride and 61 mg of diisopropylethylamine in DMF (1.0 mL) was stirred at ambient temperature for 16 h. The reaction mixture was diluted with EtOAc and washed with water and then sat. sodium chloride solution. The organic layer was dried over sodium sulfate, filtered, and concentrated. The residue was purified by silica gel chromatography to provide the title compound as a white solid. MS (M+H+)=391.4.

Provenance & Evidence