Isopropylamine → HCID 54263101, compound

HRID 223306Notes

Reaction equation

HRID 223306 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]([N:5]([CH2:12][P:13]([O:17]Cl)([O:15]Cl)=[O:14])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:4].[CH:21]([NH2:24])([CH3:23])[CH3:22]>CCOCC>[F:1][C:2]([F:20])([F:19])[C:3]([N:5]([CH2:12][P:13]([O:17][NH:24][CH:21]([CH3:23])[CH3:22])([O:15][NH:24][CH:21]([CH3:23])[CH3:22])=[O:14])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:4]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 23345669Ethyl N-trifluoroacetyl-N-(dichlorophosphonomethyl)glycinate

Product 1

HCID 54263101HCID 54263101, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of ethyl N-trifluoroacetyl-N-(dichlorophosphonomethyl)glycinate (6.6 g, 0.02 mole) in 200 ml. of ether was added dropwise with good stirring isopropylamine (4.9 g, 0.08 mole) in 70 ml. of ether. The reaction temperature was controlled by cold water bath. The reaction was stirred at room temperature overnight, then was filtered and the filtrate concentrated in vacuo. The residue was taken up in ether, washed with water, dried, concentrated in vacuo, extracted into hot petroleum ether and concentrated to give ethyl N-trifluoroacetyl-N-(bis(isopropylamino)phosphonomethyl)glycinate as a light yellow oil-gum, ND =1.4495.

Workup

  1. customThe reaction temperature was controlled by cold water bath
  2. filtrationwas filtered
  3. concentrationthe filtrate concentrated in vacuo
  4. washwashed with water
  5. customdried
  6. concentrationconcentrated in vacuo
  7. extractionextracted into hot petroleum ether
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-67be8ea5deb94450af93dae3ea31fd30
Source dataset
uspto-grants-1982_10
Patent number
US04353731

Reaction notes

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