Monomethyl terephthalate → HCID 15410718, compound

Participants

Reaction Steps

A solution of N-methyl-N-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,2-phenylenediamine (13) (0.48 mol), terephthalic acid monomethyl ester (0.48 mol), and POCl3 (0.95 mol) in dry toluene (1750 mL) is heated at 80° C. for 4 days. After cooling to room temperature, the mixture is diluted with EtOAc (1500 mL). The mixture is washed with 5 N NaOH, brine, dried over MgSO4 and evaporated in vacuo. The residue is suspended in hexane. The crystals are collected by filtration and washed with hexane to give the ester (15) (R4=CH3, Z=H) as yellow solid.

Provenance & Evidence