Acetic Acid → HCID 57438764, compound

Participants

Reaction Steps

Cyclopropyl-{4-[2-(4-fluorophenyl)-8-methoxyimidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-yl}-amine (Example #A.10.1, 0.156 g, 0.414 mmol) was treated with a 4 M solution of hydrogen bromide in acetic acid (3 mL, 12 mmol) at ambient temperature. After about 45 min the mixture was treated with Et2O and filtered, washing the solid successively with Et2O, saturated aqueous NaHCO3 and Et2O. The solid was then dried in the oven for about 16 h to yield the product as white solid (0.115 g, 77%): LC/MS (Table 1, Method b) Rt=1.7 min; MS m/z: 361.4 (M−H)−.

Provenance & Evidence