Ethanol → HCID 57438766, compound

Participants

Reaction Conditions

Reaction Steps

In a sealed tube vessel was added 8M methylamine in EtOH (10 mL, 80 mmol) and 8-chloro-2-(4-fluorophenyl)-imidazo[1,2-a]pyrazine (prepared from general procedure B using 3-chloropyrazin-2-ylamine and 2-bromo-1-(4-fluorophenyl)-ethanone; 2.30 g, 9.3 mmol). The mixture was heated at about 100° C. for about 1 h. The mixture was cooled to ambient temperature and the reaction mixture was partitioned between water and dichloromethane. The layers were separated. The organic layer was washed with brine, dried over Na2SO4, and filtered prior to concentrating under reduced pressure. The product was purified by silica gel chromatography using EtOAc/heptane (1:1) to give the title compound as a beige solid (2.05 g, 91%): LC/MS (Table 1, Method a) Rt=1.70 min; MS m/z: 243.3 (M+H)+.

Provenance & Evidence