反应详情

To a solution of decyl N-trifluoroacetyl-N-(dichlorophosphonomethyl)glycinate (6.63 g, 0.015 mole) in 200 ml. of ether was added with good stirring cyclohexylamine (5.95 g, 0.06 mole) in 50 ml. of ether. The reaction was stirred overnight at room temperature, then filtered, and the filtrate concentrated in vacuo. The residue was dissolved in fresh ether, washed with water, dried over MgSO4 and concentrated in vacuo. The residue was eluted through a dry column chromatograph with ethyl acetate to yield decyl N-trifluoroacetyl-N-(bis(cyclohexylamino)phosphonomethyl)glycinate, m.p. 79.5°-82.5° C.

1. filtrationfiltered
2. concentrationthe filtrate concentrated in vacuo
3. dissolutionThe residue was dissolved in fresh ether
4. washwashed with water
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo
7. washThe residue was eluted through a dry column chromatograph with ethyl acetate