反应详情

温度

80 °C

A suspension of 2-(4-fluorophenyl)-8-isopropoxy-3-(2-methanesulfonylpyrimidin-4-yl)-imidazo[1,2-a]pyrazine (0.16 g, 0.37 mmol) and 3-amino-2,2-dimethylpropan-1-ol (TCI-US, 0.208 g, 0.74 mmol) in ACN (5 mL) was heated at about 80° C. overnight to give a clear solution. The reaction mixture was cooled to ambient temperature, the volatiles were evaporated, and the resulting residue was dissolved in DCM and washed with water. The organic phase was dried over MgSO4, filtered, and evaporated to give a white solid that was triturated with heptane to afford 0.109 g (64.7%) the title compound as a white solid: LC/MS (Table 1, Method g) Rt=3.01 min; MS m/z: 494.2 (M+H)+.

1. customto give a clear solution
2. temperatureThe reaction mixture was cooled to ambient temperature
3. customthe volatiles were evaporated
4. dissolutionthe resulting residue was dissolved in DCM
5. washwashed with water
6. dry with materialThe organic phase was dried over MgSO4
7. filtrationfiltered
8. customevaporated
9. customto give a white solid
10. customthat was triturated with heptane