Hydrochloric Acid → HCID 57438777, compound

Participants

Reaction Steps

3-{4-[2-(4-Fluorophenyl)-8-methylimidazo[1,2-a]pyrazin-3-yl]pyrimidin-2-ylamino}-2,2-dimethyl-propionic acid ethyl ester (Example #A.9.19, 0.085 g, 0.19 mmol) was diluted in MeOH (3 mL) and treated with 2.5 M NaOH (0.36 mL, 0.9 mmol) at ambient temperature. After about 4 days, the mixture was neutralized with 1.0 M HCl (0.90 mL, 0.9 mmol) and diluted with DCM and water. The layers were separated and the aqueous layer was extracted with DCM. The combined organic layers were dried over Na2SO4, decanted, and concentrated to yield the title compound (0.036 g, 45%): LC/MS (Table 1, Method b) Rt=1.9 min; MS m/z: 421.3 (M+H)+.

Provenance & Evidence