Triethylamine → Methyl 4-[(pyridine-3-ylmethyl)-amino]-cyclohexane-carboxylate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

6.13 g of pyridine-3-aldehyde, 5.77 g of triethylamine and 9 g of methyl 4-amino-cyclohexanecarboxylate are mixed into 250 ml of methanol. 3 g of Raney nickel are added thereto un order to hydrogenate the mixture, with stirring, for about 6.5 hours at 50° C. and 3 bar. After the catalyst has been eliminated by suction filtering the filtrate is evaporated down. The crude product is purified through silica gel with methylene chloride/methanol.

Herkunft & Nachweise