Hydrochloric Acid → HCID 68445055, compound

Participants

Reaction Steps

A solution of 1,1-dimethylethyl {1-[(7-fluoro-3-oxo-5,6-dihydro-3H-pyrrolo[1,2,3-de]quinoxalin-6-yl)methyl]-4-piperidinyl}carbamate (8.13 g, 20.2 mmol) in dichloromethane (150 ml) and methanol (100 ml) was cooled in iced water. Hydrogen chloride in 1,4-dioxane (4M, 160 ml) was added gradually, then the mixture was stirred for 1.5 h. The mixture was evaporated and the residue was triturated with ether and filtered off. The solid was partially dissolved in 25% methanol/dichloromethane (200 ml) and stirred with MP-carbonate (3.03 mmol/g, 27 g) for 1 h. The resin was filtered off, washed a few times with 10% methanol/dichloromethane and methanol alternately, and the filtrate was evaporated to give the product (5.96 g, 98%).

Provenance & Evidence