Furo[2,3-c]pyridin-5-ylmethanol → 2,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol

HRID 2233182Notes

Reaction equation

HRID 2233182 reaction equation
[O:1]1[C:5]2=[CH:6][N:7]=[C:8]([CH2:10][OH:11])[CH:9]=[C:4]2[CH:3]=[CH:2]1>C(O)C.[Pd]>[O:1]1[C:5]2=[CH:6][N:7]=[C:8]([CH2:10][OH:11])[CH:9]=[C:4]2[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 22047174Furo[2,3-c]pyridin-5-ylmethanol

Product 1

HCID 574231212,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Furo[2,3-c]pyridin-5-ylmethanol (1.29 g, 8.7 mmol) was dissolved in ethanol (50 ml) and hydrogenated at RT, 1 atmosphere over 10% palladium on charcoal paste for 18 h. The mixture was filtered through kieselguhr and the filtrate evaporated to dryness, to give (1.31 g, 100%).

Workup

  1. filtrationThe mixture was filtered through kieselguhr
  2. customthe filtrate evaporated to dryness
  3. customto give (1.31 g, 100%)

Sources & evidence

ORD record
ord-68cff28758074e0dadb198ae5095a850
Source dataset
uspto-grants-2010_05
Patent number
US07709483B2

Reaction notes

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