HCID 68448458, compound → HCID 68446005, compound

Participants

Reaction Steps

A mixture of 7-fluoro-6-hydroxy-6-(hydroxymethyl)-1,2,5,6-tetrahydro-3H-pyrrolo[1,2,3-de]quinoxalin-3-one (0.331 g, 0.001 mol), and manganese (IV) oxide (1.84 g, 0.021 mol) in DMF (50 mL) was stirred at room temperature for 1 hour. The reaction mixture was filtered through Celite®, washed with methanol and the solvent was removed. The residue was placed directly onto the top of a 20 g silica gel column and chromatographed, eluting with a 0-100% ethyl acetate in hexane gradient, then with a 0-50% methanol in ethyl acetate gradient to afford the product (0.267 g, 81%).

Provenance & Evidence