HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-nitrobenzoate → Ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-aminobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-nitrobenzoate | HCID 11773033 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-aminobenzoate | HCID 11809903 | 100.4% |
Reaction Steps
A suspension of ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-nitrobenzoate (132.2 g, 359 mmol) and 10% palladium on carbon (3.0 g) in a mixture of ethanol (200 ml) and ethyl acetate (2000 ml) was stirred under an atmosphere of hydrogen for 18 hours. Removal of the catalyst by filtration, followed by solvent evaporation in vacuo yielded ethyl 3-methoxy-4-(3-morpholinopropoxy)-6-aminobenzoate (122 g, 100% yield) as a brown oil:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709479B1 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-34256ff2d1ba4da4a13d479874053693 |
| Source note | uspto-grants-2010_05 |