反应详情

14.5 g (0.050 mol) of 6-iodoisatoic acid anhydride and 6.6 g (0.058 mol) of L-proline in 50 ml of dimethyl sulphoxide are warmed to 70° for 30 minutes, the solvent is removed in a high vacuum and the oil obtained is heated at 170° for 15 minutes. The crude product is purified by chromatography on silica gel using methylene chloride and a mixture of methylene chloride and ethyl acetate for the elution. There is obtained (S)-1,2,3,11a-tetrahydro-6-iodo-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione which melts at 212°-215° after recrystallization from methanol.

1. customthe solvent is removed in a high vacuum
2. customthe oil obtained
3. temperatureis heated at 170° for 15 minutes
4. customThe crude product is purified by chromatography on silica gel
5. additiona mixture of methylene chloride and ethyl acetate
6. washfor the elution