Triethylamine → HCID 86761097, compound

Participants

Reaction Steps

Triethylamine (4.5 ml, 32.0 mmol) was added to a stirred solution of, N-(tert-butoxy-carbonyl)-3-hydroxypyrrolidine (2.00 g, 10.7 mmol) in diethyl ether (100 ml) and the reaction was cooled to 0° C. before addition of methanesulphonyl chloride (1.65 ml, 21.4 mmol) and stirring for 2 hours, warming from 0° C. to ambient temperature. The reaction was filtered, the filtrate was washed with 1.0 N hydrochloric acid (100 ml) and with brine (100 ml) before being dried over magnesium sulphate. Solvent evaporation in vacuo yielded N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine methanesulphonate (2.9 g, 100% yield) as a colourless oil:

Provenance & Evidence