Methyl 4-aminobenzoate → 6,7-Dimethoxyquinazoline

Participants

Reaction Steps

A solution of methyl 4-aminobenzoate (151 mg, 1.00 mmol) and 4-chloro-6,7-dimethoxyquinazoline (224 mg, 1.00 mmol) in isopropanol (200 ml) was heated at reflux for 3 hours before the reaction was allowed to cool to ambient temperature. The solid which had precipitated was collected by suction filtration and washed with diethyl ether (2×50 ml). Drying of this material yielded 4-(4-carbomethoxy)anilino)-6,7-dimethoxyquinazoline (363 mg, 97% yield) as a white solid:

Provenance & Evidence