Acetic Acid → HCID 59295421, compound

Participants

Reaction Conditions

Reaction Steps

1.25 g 2-(1-Bromo-cyclohexyl)-4-bromomethyl-oxazole-5-carboxylic acid ethyl ester was dissolved in 15 ml ethanol. 176 mg sodium hydride were added and the reaction mixture stirred at 65° C. for one hour. The cooled reaction mixture was neutralized by the addition of acetic acid (pH˜6). 50 mg palladium on charcoal (10%) were added and the reaction mixture was stirred under an atmosphere of hydrogen for one hour. The catalyst was filtered off through a pad of celite, the filtrate was evaporated in vacuo and the resulting crude material was purified by reversed phase HPLC to obtain 370 mg 2-Cyclohexyl-4-ethoxymethyl-oxazole-5-carboxylic acid ethyl ester as an oil.

Provenance & Evidence