Trifluoroacetic acid → HCID 59295393, compound

Participants

Reaction Steps

4.5 g 4-[5-(3-Chloro-4-cyano-phenoxymethyl)-4-methyl-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (derived from 4-(5-Chloromethyl-4-methyl-thiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester and commercially available 2-Chloro-4-hydroxy-benzonitrile according to the method described in Example 1) was dissolved in 100 ml dichloromethane. 20 ml trifluoroacetic acid were added and the reaction mixture stirred at room temperature for one hour. The solvent was removed in vacuo and the residue was dissolved in 200 ml ethyl acetate, washed three times with saturated NaHCO3 solution and then dried over MgSO4. The solvent was removed in Vacuo to obtain 3.5 g 2-Chloro-4-(4-methyl-2-piperidin-4-yl-thiazol-5-ylmethoxy)-benzonitrile as colorless solid.

Provenance & Evidence