HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Proline → (S)-1,2,3,11a-tetrahydro-6-methoxy-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 5-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione | HCID 10750295 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (S)-1,2,3,11a-tetrahydro-6-methoxy-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione | HCID 54525802 | — |
Reaction Steps
4.8 g (0.025 mmol) of 6-methoxyisatoic acid anhydride and 3.0 g (0.026 mol) of L-proline in 40 ml of dimethyl sulphoxide is heated to 70° for 2 hours, the solvent is removed in a high vacuum and the oil obtained is heated to 170° for 15 minutes. After treatment with active carbon, the crude product is recrystallized from methanol, there being obtained (S)-1,2,3,11a-tetrahydro-6-methoxy-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione of melting point 247°-251°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04353827 |
| Source dataset | uspto-grants-1982_10 |
| ORD ID | ord-277d891ef42f47e7bfffc49765bd0b69 |
| Source note | uspto-grants-1982_10 |