Sodium Hydroxide → HCID 58730629, compound

HRID 2233321Notes

Reaction equation

HRID 2233321 reaction equation
C[O:2][C:3](=[O:42])[CH2:4][CH:5]1[C:14]2[C:9](=[C:10]([F:15])[CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=3)=[CH:18][CH:17]=2)[N:6]1[C:30]1[CH:35]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:33]=[CH:32][C:31]=1[O:40][CH3:41].[OH-].[Na+]>O1CCOCC1>[CH3:29][O:28][C:24]1[CH:23]=[C:22]([C:19]2[CH:20]=[CH:21][C:16]([C:7]3[N:6]([C:30]4[CH:35]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:33]=[CH:32][C:31]=4[O:40][CH3:41])[CH:5]([CH2:4][C:3]([OH:42])=[O:2])[C:14]4[C:9](=[C:10]([F:15])[CH:11]=[CH:12][CH:13]=4)[N:8]=3)=[CH:17][CH:18]=2)[CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58730640HCID 58730640, compound

Product 1

HCID 58730629HCID 58730629, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Starting from 459 mg (0.79 mmol) of the ester from Example 22A, reaction in analogy to general method [E] with 95.2 mg (2.38 mmol) of sodium hydroxide in 54 ml of dioxane results in 383 mg (86% of theory) of the target compound.

Workup

  1. customresults in 383 mg (86% of theory) of the target compound

Sources & evidence

ORD record
ord-267064bdd3df4e9a9f44fe8181ef61a5
Source dataset
uspto-grants-2010_05
Patent number
US07709491B2

Reaction notes

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