Formaldehyde → 3-Bromo-2-hydroxybenzaldehyde

Participants

Reaction Steps

To a solution of 2-bromophenol (3.17 g, 18.3 mmol) in acetonitrile (85 mL) was added magnesium chloride (2.62 g, 27.5 mmol), paraformaldehyde (3.7 g, 0.13 mmol) and Et3N (6.4 ml, 46 mmol). The reaction was heated at reflux for 3 h, allowed to cool, diluted with 1 N HCl (100 mL, and extracted with ethyl acetate. The organic layer was washed with aqueous sodium chloride, dried (MgSO4), and concentrated to afford the title compound (3.74 g, 100%): MS (ES) m/e 202.1 (M+H)+. This was used without further purification.

Provenance & Evidence