HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methanol → 2,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methanol | HCID 21873770 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde | HCID 21873668 | 61% |
Reaction Steps
A solution of 2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethanol (250 mg, 1.5 mmole) in CH2Cl2 (5 mL) was treated with MnO2 (650 mg, 7.5 mmole). After 3 days the mixture was filtered and the filtrate was concentrated to afford the title compound (150 mg, 61%) as a white solid: MS (APCI+) m/e 166 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709496B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-15888ed1e1ce4b06ac98bc393fb0ea2d |
| Source note | uspto-grants-2010_05 |