反应详情

To a solution of 8-(2-propen-1-yl)-2H-chromen-2-one (390 mg, 2.0 mmol) in dioxane (10 mL) and water (5 mL) was added OsO4 (4% solution in H2O, 0.5 mL, 10 mol %) and NaIO4 (430 mg, 4.0 mmol). The reaction was stirred at RT for 2 h and NaIO4 (430 mg, 4.0 mmol) was added and the reaction was allowed to stir another 2 h. The reaction was diluted with 20 mL of H2O and was extracted with ethyl acetate (3×50 mL). The combined extracts were dried (Na2SO4), and concentrated to give the title compound (350 mg, 93%) as a dark oil which was used without further purification: MS (ES) m/e 188.9 (M+H)+.

1. stirringto stir another 2 h
2. extractionwas extracted with ethyl acetate (3×50 mL)
3. dry with materialThe combined extracts were dried (Na2SO4)
4. concentrationconcentrated