反应详情

A solution of mixture of 2-{4-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-3-hydroxybutyl}-1H-isoindole-1,3(2H)-dione (3.00 g) in a mixture of ethanol (75 ml) and 35% aqueous hydrazine (15 ml) was heated at reflux 4 h. The mixture was cooled down and the solvents removed under vacuum. The residue was triturated with warm dichloromethane. The white solid was removed by filtration and the filtrate dried over sodium sulfate. The mixture was filtered and the solvent was evaporated to afford the title compound as a yellow oil (2.10 g) which was used without further purification in the next step.

1. temperaturewas heated
2. temperatureat reflux 4 h
3. temperatureThe mixture was cooled down
4. customthe solvents removed under vacuum
5. customThe residue was triturated with warm dichloromethane
6. customThe white solid was removed by filtration
7. dry with materialthe filtrate dried over sodium sulfate
8. filtrationThe mixture was filtered
9. customthe solvent was evaporated