Triethylamine → HCID 68582989, compound

Participants

Reaction Steps

A solution of 4-(3,4-dichlorophenoxy)piperidine (0.985 g, 4 mmoles), 2-[[(2R)-2-methyloxiranyl]methyl]-1H-isoindole-1,3(2H)-dione (0.869 g, 4 mmoles) and triethylamine (0.809 g, 1.12 ml, 8 mmoles) in ethanol (20 ml) was stirred at 50° C. for 5 h. The resulting solution was cooled to room temperature and concentrated in vacuo to leave a crude yellow gum. Flash chromatography (silica, 2% of 7N methanolic ammonia in dichloromethane as eluant) afforded the subtitle compound as a yellow oil (1.24 g).

Provenance & Evidence