Chlorosulfonic acid → HCID 59295966, compound

HRID 2233380Notes

Reaction equation

HRID 2233380 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([S:12](O)(=[O:14])=[O:13])[CH:10]=2)[C:5]([C:16]([OH:18])=[O:17])=[CH:4][NH:3]1.[Cl:19]S(O)(=O)=O>>[Cl:19][S:12]([C:9]1[CH:10]=[C:11]2[C:6]([C:5]([C:16]([OH:18])=[O:17])=[CH:4][NH:3][C:2]2=[O:1])=[CH:7][CH:8]=1)(=[O:14])=[O:13]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 865980711-Oxo-7-sulfo 1,2-dihydroisoquinoline-4-carboxylic acid

Product 1

HCID 59295966HCID 59295966, compound

Conditions

Temperature
100 °C

Procedure

1-Oxo-7-sulfo 1,2-dihydroisoquinoline-4-carboxylic acid (5 g) was added to chlorosulphonic acid (25 ml). The mixture was heated at 100° C. for 84 h and then slowly dripped onto ice with sting. The mixture was filtered and the residue was washed with water and ether and dried to yield 7-(chlorosulfonyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid as a buff solid (7.5 g).

Workup

  1. filtrationThe mixture was filtered
  2. washthe residue was washed with water and ether
  3. customdried

Sources & evidence

ORD record
ord-44484a78e69841d9a4053e6babcc5d1b
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

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