Cyclopropylamine → 2-Methylpentane

Participants

Reaction Steps

A solution of tert-butyl 4-[3,4-dichloro-2-(1H-imidazol-1-ylcarbonyl)phenoxy]piperidine-1-carboxylate (described in Preparation 11 step 1) (2.0 g, 4.5 mmol) in cyclopropylamine (12 ml) was heated at 50° C. for 14 h. The solution was concentrated in vacuo then partitioned between ethyl acetate and 1N aqueous hydrochloric acid. The organics were dried over magnesium sulfate and concentrated in vacuo. Crystallization from dichloromethane:isohexane gave the title compound as a white solid (0.64 g).

Provenance & Evidence