Sulfuric Acid → Methyl 6-fluoro-1-oxo-1H-2-benzopyran-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a suspension of (4Z)-6-fluoro-4-(methoxymethylene)-1H-isochromene-1,3(4H)-dione (1.30 g) in methanol (20 ml) was slowly added sulfuric acid (1.5 ml). The mixture was heated at 40-50° C. for 3 h. As the reaction proceeded the sub-title compound crystallized out. The reaction was cooled to room temperature and a white solid was collected by filtration and washed with cold methanol.

Provenance & Evidence