HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2233396Generated: October 29, 2026
Ammonium Acetate → Methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate
https://huagongshe.com/reaction/2233396
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | Methyl 6-fluoro-1-oxo-1H-2-benzopyran-4-carboxylate | HCID 53429436 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate | HCID 53429435 | — |
Reaction Steps
A mixture of methyl 6-fluoro-1-oxo-1H-isochromene-4-carboxylate (1.53 g) and ammonium acetate (2.5 g) in 4 ml of glacial acetic acid was heated at 80° C. for 16 h. The reaction was cooled to 40° C., diluted with 8 ml of water and the solid collected by filtration (1.38 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07709500B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-0696056d71c94423a6f96b4a14231836 |
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| Source note | uspto-grants-2010_05 |
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