HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 7-methoxy-4-phenyl-6-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-phenyl-2H-1-benzopyran-2-one | HCID 19927731 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 7-methoxy-4-phenyl-6-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927660 | 86% |
Reaction Steps
Method B (60 h at 60° C.); starting materials: 6-[3-(methanesulfonyloxy)propoxy]-7-methoxy-4-phenyl-2H-1-benzopyran-2-one (example 78) and 1-phenylpiperazine; yield 86%; fusion point 139°-141° C. (from TBME and isopropanol). Fumarate: method E; yield 93%; fusion point 145°-147° C. (from acetone and diethylether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-a08790196abb44409d3a618f7872e071 |
| Source note | uspto-grants-1995_06 |