2486-69-3 → 4-Amino-N-{(2R)-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-3-methoxybenzamide

HRID 2233400Notes

Reaction equation

HRID 2233400 reaction equation
[NH2:1][CH2:2][C@@H:3]([OH:20])[CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=2)[CH2:7][CH2:6]1.[NH2:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](O)=[O:27])=[CH:24][C:23]=1[O:31][CH3:32]>>[NH2:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([NH:1][CH2:2][C@@H:3]([OH:20])[CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([O:11][C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=3)[CH2:7][CH2:6]2)=[O:27])=[CH:24][C:23]=1[O:31][CH3:32]

Participants

3

Reactant 2

HCID 2880572486-69-3HCID 11151315(2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl)propan-2-ol

Product 1

HCID 592960394-Amino-N-{(2R)-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-3-methoxybenzamide

Procedure

Prepared as described in Example 1 from (2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propan-2-ol (0.1 g) and 4-amino-3-methoxybenzoic acid (0.052 g). Title compound obtained as white solid (0.053 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fe2d09976ec140709c3e769c2bab3086
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

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