HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methanesulfonylthiophene-2-carboxylic acid → N-{(2R)-3-[4-(3,4-Dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-5-(methylsulfonyl)thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methanesulfonylthiophene-2-carboxylic acid | HCID 2740497 | — |
| Reactant | (2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl)propan-2-ol | HCID 11151315 | — |
| Product | N-{(2R)-3-[4-(3,4-Dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-5-(methylsulfonyl)thiophene-2-carboxamide | HCID 59296085 | — |
Reaction Steps
Prepared as described in Example 1 from (2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propan-2-ol (0.1 g) and 5-(methylsulfonyl)thiophene-2-carboxylic acid (0.065 g). Title compound obtained as white solid (0.039 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709500B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-4b84bbc3e0aa41109161c48fde13b069 |
| Source note | uspto-grants-2010_05 |