(2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl)propan-2-ol → HCID 68439564, compound

HRID 2233404Notes

Reaction equation

HRID 2233404 reaction equation
[NH2:1][CH2:2][C@@H:3]([OH:20])[CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=2)[CH2:7][CH2:6]1.[O:21]=[C:22]1[NH:26][C:25]2[CH:27]=[CH:28][C:29]([C:31]([OH:33])=[O:32])=[CH:30][C:24]=2[S:23]1>>[C:31]([OH:33])(=[O:32])[CH3:29].[Cl:19][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][C:15]=1[Cl:18])[O:11][CH:8]1[CH2:9][CH2:10][N:5]([CH2:4][C@H:3]([OH:20])[CH2:2][NH:1][C:31]([C:29]2[CH:28]=[CH:27][C:25]3[NH:26][C:22](=[O:21])[S:23][C:24]=3[CH:30]=2)=[O:32])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 11151315(2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl)propan-2-olHCID 141167092-Hydroxy-1,3-benzothiazole-6-carboxylic acid

Product 1

HCID 68439564HCID 68439564, compound

Procedure

Prepared as described in Example 1 from (2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propan-2-ol (0.1 g) and 2-oxo-2,3-dihydro-1,3-benzothiazole-6-carboxylic acid (0.061 g). Title compound obtained as acetate salt, a white solid (0.10 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bb820659bb0d4b629e35100aad33f449
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

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