(2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl)propan-2-ol → HCID 59296114, compound

HRID 2233405Notes

Reaction equation

HRID 2233405 reaction equation
[NH2:1][CH2:2][C@@H:3]([OH:20])[CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=2)[CH2:7][CH2:6]1.[F:21][C:22]1[CH:23]=[CH:24][C:25]2[N:26]([CH:28]=[C:29]([C:31](O)=[O:32])[N:30]=2)[CH:27]=1>>[Cl:19][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][C:15]=1[Cl:18])[O:11][CH:8]1[CH2:9][CH2:10][N:5]([CH2:4][C@H:3]([OH:20])[CH2:2][NH:1][C:31]([C:29]2[N:30]=[C:25]3[CH:24]=[CH:23][C:22]([F:21])=[CH:27][N:26]3[CH:28]=2)=[O:32])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 11151315(2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl)propan-2-olHCID 223975086-Fluoroimidazo[1,2-a]pyridine-2-carboxylic acid

Product 1

HCID 59296114HCID 59296114, compound

Procedure

Prepared as described in Example 1 from (2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propan-2-ol (0.1 g) and 6-fluoroimidazo[1,2-a]pyridine-2-carboxylic acid (0.056 g). Title compound obtained as white solid (0.076 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-15cec4b045e549b3a73083563482d64d
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

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