HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Oxo-1,2-dihydroisoquinoline-4-carboxylic acid → N-{(2R)-3-[4-(3,4-Dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-1-oxo-1,2-dihydroisoquinoline-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Oxo-1,2-dihydroisoquinoline-4-carboxylic acid | HCID 643161 | — |
| Reactant | (2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl)propan-2-ol | HCID 11151315 | — |
| Product | N-{(2R)-3-[4-(3,4-Dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-1-oxo-1,2-dihydroisoquinoline-4-carboxamide | HCID 9870185 | — |
Reaction Steps
Prepared as described in Example 1 from (2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propan-2-ol (0.1 g) and 1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid (0.059 g). Title compound obtained as white solid (0.047 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07709500B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-452a7efc5b324ea1bf0f271bd88f456b |
| Source note | uspto-grants-2010_05 |