Benzothiazole-6-carboxylic acid → HCID 59295917, compound

HRID 2233407Notes

Reaction equation

HRID 2233407 reaction equation
[NH2:1][CH2:2][C@@H:3]([OH:20])[CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=2)[CH2:7][CH2:6]1.[S:21]1[C:25]2[CH:26]=[C:27]([C:30](O)=[O:31])[CH:28]=[CH:29][C:24]=2[N:23]=[CH:22]1>>[Cl:19][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][C:15]=1[Cl:18])[O:11][CH:8]1[CH2:9][CH2:10][N:5]([CH2:4][C@H:3]([OH:20])[CH2:2][NH:1][C:30]([C:27]2[CH:28]=[CH:29][C:24]3[N:23]=[CH:22][S:21][C:25]=3[CH:26]=2)=[O:31])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 601670Benzothiazole-6-carboxylic acidHCID 11151315(2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl)propan-2-ol

Product 1

HCID 59295917HCID 59295917, compound

Procedure

Prepared as described in Example 1 from (2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propan-2-ol (0.1 g) and 1,3-benzothiazole-6-carboxylic acid (0.056 g). Title compound obtained as white solid (0.066 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-052610c70bae4629934c4f0c1343a5c4
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

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