3-Cyanobenzoic acid → HCID 59296064, compound

HRID 2233408Notes

Reaction equation

HRID 2233408 reaction equation
[NH2:1][CH2:2][C@@H:3]([OH:20])[CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=2)[CH2:7][CH2:6]1.[C:21]([C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=1)[C:26](O)=[O:27])#[N:22]>>[C:21]([C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=1)[C:26]([NH:1][CH2:2][C@@H:3]([OH:20])[CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([Cl:19])[CH:13]=2)[CH2:7][CH2:6]1)=[O:27])#[N:22]

Participants

3

Reactant 2

HCID 158753-Cyanobenzoic acidHCID 11151315(2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl)propan-2-ol

Product 1

HCID 59296064HCID 59296064, compound

Procedure

Prepared as described in Example 1 from (2R)-1-amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propan-2-ol (0.2 g) and 3-cyanobenzoic acid (0.092 g). Title compound obtained as white solid (0.050 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-cc30cbc0cf114809803a0a17124f2578
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

Loading…