2-Methanesulfonylbenzoic acid → N-{4-[4-(3,4-Dichlorophenoxy)piperidin-1-yl]-3-hydroxybutyl}-2-(methylsulfonyl)benzamide

HRID 2233409Notes

Reaction equation

HRID 2233409 reaction equation
[NH2:1][CH2:2][CH2:3][CH:4]([OH:21])[CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([O:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([Cl:20])[CH:14]=2)[CH2:8][CH2:7]1.[CH3:22][S:23]([C:26]1[CH:34]=[CH:33][CH:32]=[CH:31][C:27]=1[C:28](O)=[O:29])(=[O:25])=[O:24]>>[Cl:20][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][C:16]=1[Cl:19])[O:12][CH:9]1[CH2:8][CH2:7][N:6]([CH2:5][CH:4]([OH:21])[CH2:3][CH2:2][NH:1][C:28](=[O:29])[C:27]2[CH:31]=[CH:32][CH:33]=[CH:34][C:26]=2[S:23]([CH3:22])(=[O:25])=[O:24])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 2843422-Methanesulfonylbenzoic acidHCID 592960694-Amino-1-[4-(3,4-dichlorophenoxy)piperidin-1-yl]butan-2-ol

Product 1

HCID 59296067N-{4-[4-(3,4-Dichlorophenoxy)piperidin-1-yl]-3-hydroxybutyl}-2-(methylsulfonyl)benzamide

Procedure

Prepared as described in Example 1 from 4-amino-1-[4-(3,4-dichlorophenoxy)piperidin-1-yl]butan-2-ol (0.26 g) and 2-(methylsulphonyl)benzoic acid (0.156 g). The title compound was obtained as a white solid (0.170 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ae22514fe72c406094bafe5da0cee0bf
Source dataset
uspto-grants-2010_05
Patent number
US07709500B2

Reaction notes

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