Sulfuryl chloride → HCID 68580435, compound

Participants

Reaction Steps

(2R)-1-Amino-3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]propan-2-ol (0.1 g) in pyridine (2 ml) was treated with 1-oxo-1,2-dihydroisoquinoline-4-sulfonyl chloride (0.11 g) and the mixture was stirred at ambient temperature for 18 h. After further additions of the sulfonyl chloride (0.05 g) and stirring for 24 h the solvent was evaporated. Purification by column chromatography and reverse phase HPLC (symmetry C8 column and acetonitrile/0.1% aqueous ammonium acetate) yielded the title compound as a white solid (0.06 g).

Provenance & Evidence