Benzeneacetonitrile, 3-fluoro- → HCID 22299529, compound

HRID 2233419Notes

Reaction equation

HRID 2233419 reaction equation
C(O[C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[N:7][CH:6]=1)C.[F:12][C:13]1[CH:14]=[C:15]([CH2:19][C:20]#[N:21])[CH:16]=[CH:17][CH:18]=1>>[F:12][C:13]1[CH:14]=[C:15]([CH2:19][C:4]([C:5]2[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=2)=[O:11])[CH:16]=[CH:17][CH:18]=1.[F:12][C:13]1[CH:14]=[C:15]([CH2:19][CH:20]([NH2:21])[C:5]2[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=2)[CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 68145Benzeneacetonitrile, 3-fluoro-HCID 69188Ethyl Nicotinate

Product 2

HCID 22299529HCID 22299529, compoundHCID 60797988HCID 60797988, compound

Procedure

The title compound was generated from commercially available nicotinic acid ethyl ester and (3-fluoro-phenyl)-acetonitrile according to the general procedure D described above. The intermediates 2-(3-fluoro-phenyl)-1-pyridin-3-yl-ethanone and 2-(3-fluoro-phenyl)-1-pyridin-3-yl-ethylamine were isolated and characterized.

Sources & evidence

ORD record
ord-c3915b3dd0e64160aadd99935c821724
Source dataset
uspto-grants-2010_05
Patent number
US07709507B2

Reaction notes

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