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HRID223342

反应详情

EQUATION

反应方程式

HRID 223342 的结构方程式

REACTANTS

反应物

3
结构：O=S(=O)(O)O
HCID1118

Sulfuric acid

H2O4S

结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：C=C1C[C@@]23CC[C@H]4[C@@](C)(CCC[C@@]4(C)C(=O)O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H]2CC[C@]1(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O)C3
HCID44564215

未命名化合物

PRODUCTS

生成物

1
结构：C=C1C[C@@]23CC[C@H]4[C@@](C)(CCC[C@@]4(C)C(=O)O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H]2CC[C@]1(O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O)[C@@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O)C3
HCID44564216

未命名化合物

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Rebaudioside A (0.2 mmol, 183 mg) was transferred to a 15 ml flask. Four ml each of 10% KOH and methanol were added and the resultant mixture heated to yield a homogeneous solution which was refluxed for 11/2 h. Reaction was than judged complete by TLC analysis. After cooling to 0°; the reaction mixture was acidified to pH3 with 10% H2SO4. The resultant mixture (primarily rebaudioside C) was then concentrated to dryness and the residue recrystallized from water to give 150 mg (99%) of pure rebaudioside C.

WORKUP

后处理

  1. customto yield a homogeneous solution which
  2. temperaturewas refluxed for 11/2 h
  3. customReaction
  4. temperatureAfter cooling to 0°
  5. concentrationThe resultant mixture (primarily rebaudioside C) was then concentrated to dryness
  6. customthe residue recrystallized from water