Ethyl isonicotinate → HCID 68579665, compound

HRID 2233423Notes

Reaction equation

HRID 2233423 reaction equation
C(O[C:4](=[O:11])[C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)C.[F:12][C:13]1[CH:14]=[C:15]([CH2:20][C:21]#[N:22])[CH:16]=[CH:17][C:18]=1[F:19]>>[F:12][C:13]1[CH:14]=[C:15]([CH2:20][C:4]([C:5]2[CH:6]=[CH:7][N:8]=[CH:9][CH:10]=2)=[O:11])[CH:16]=[CH:17][C:18]=1[F:19].[F:12][C:13]1[CH:14]=[C:15]([CH2:20][CH:21]([NH2:22])[C:5]2[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=2)[CH:16]=[CH:17][C:18]=1[F:19]

Participants

4

Reactant 2

HCID 15291Ethyl isonicotinateHCID 69572(3,4-Difluorophenyl)acetonitrile

Product 2

HCID 68579665HCID 68579665, compoundHCID 68579993HCID 68579993, compound

Procedure

The title compound was generated from commercially available isonicotinic acid ethyl ester and (3,4-difluoro-phenyl)-acetonitrile according to the general procedure D described above. The intermediates 2-(3,4-difluoro-phenyl)-1-pyridin-4-yl-ethanone and 2-(3,4-difluoro-phenyl)-1-pyridin-4-yl-ethylamine were isolated and characterized.

Sources & evidence

ORD record
ord-d2024a8a21a2440b8f34a91a6ff619f0
Source dataset
uspto-grants-2010_05
Patent number
US07709507B2

Reaction notes

Loading…