Ethyl Nicotinate → HCID 61675221, compound

HRID 2233425Notes

Reaction equation

HRID 2233425 reaction equation
C(O[C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[N:7][CH:6]=1)C.[F:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=1[CH2:20][C:21]#[N:22]>>[F:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=1[CH2:20][C:4]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1)=[O:11].[F:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=1[CH2:20][CH:21]([NH2:22])[C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 69188Ethyl NicotinateHCID 592780(2,5-Difluorophenyl)acetonitrile

Product 2

HCID 61675221HCID 61675221, compoundHCID 61675385HCID 61675385, compound

Procedure

The title compound was generated from commercially available nicotinic acid ethyl ester and (2,5-difluoro-phenyl)-acetonitrile according to the general procedure D described above. The intermediates 2-(2,5-difluoro-phenyl)-1-pyridin-3-yl-ethanone and 2-(2,5-difluoro-phenyl)-1-pyridin-3-yl-ethylamine were isolated and characterized.

Sources & evidence

ORD record
ord-54884bdde64647758d3378a8fec2e27c
Source dataset
uspto-grants-2010_05
Patent number
US07709507B2

Reaction notes

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