Bromine → HCID 377336, compound

HRID 223352Notes

Reaction equation

HRID 223352 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[CH2:6][CH2:5][C:4]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH:19]=[CH:18][N:17]=[CH:16]3)=[CH:11][CH:10]=2)=[N:3]1.[OH:20][CH2:21][CH2:22][N:23]1[C:28](=[O:29])[CH2:27][CH2:26][C:25]([C:30]2[CH:35]=[CH:34][C:33]([N:36]3[CH:40]=[CH:39][N:38]=[CH:37]3)=[CH:32][CH:31]=2)=[N:24]1.BrBr>C(O)(=O)C>[CH3:1][N:2]1[C:7](=[O:8])[CH:6]=[CH:5][C:4]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH:19]=[CH:18][N:17]=[CH:16]3)=[CH:13][CH:14]=2)=[N:3]1.[OH:20][CH2:21][CH2:22][N:23]1[C:28](=[O:29])[CH:27]=[CH:26][C:25]([C:30]2[CH:31]=[CH:32][C:33]([N:36]3[CH:40]=[CH:39][N:38]=[CH:37]3)=[CH:34][CH:35]=2)=[N:24]1

Participants

6

Reactant 3

HCID 24408BromineHCID 357537HCID 357537, compoundHCID 13233881HCID 13233881, compound

Product 2

HCID 377336HCID 377336, compoundHCID 20146322HCID 20146322, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using the procedure of this Example, reaction of 4,5-dihydro-2-methyl-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone and 4,5-dihydro-2-[2-hydroxyethyl]-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone with bromine in acetic acid gives 2-methyl-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone and 2-[2-hydroxyethyl]-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone respectively.

Sources & evidence

ORD record
ord-6006125c53bf4714913e2537f88732a0
Source dataset
uspto-grants-1982_10
Patent number
US04353905

Reaction notes

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