Hydrochloric Acid → HCID 58934102, compound

Participants

Reaction Steps

1.2 g lithium aluminium hydride was dissolved in 100 ml dry tetrahydrofuran. 5.3 g 4-Butyl-2-(4-trifluormethyl-phenyl)-thiazol-5-carboxylic acid methyl ester, dissolved in 100 ml tetrahydrofuran, were added. The reaction mixture was stirred at room temperature over a period of one hour, then 50 ml saturated ammonium chloride solution and 50 ml of a 1 molar hydrochloric acid solution were added. The reaction mixture was extracted five times with portions of 60 ml of ethyl acetate. The combined organic layers were dried over MgSO4 and the solvent removed under reduced pressure to provide 4.6 g [4-Butyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-yl]-methanol as a yellow oil, which solidified upon standing at room temperature.

Provenance & Evidence