1-(2-Methoxyphenyl)piperazine → HCID 12961751, compound

HRID 223357Notes

Reaction equation

HRID 223357 reaction equation
[O:1]1[CH2:16][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[O:12][CH:13]=[N:14][N:15]=1.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>C(O)C>[O:12]1[CH:13]=[N:14][N:15]=[C:11]1[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[O:4][CH2:3][CH:2]([OH:1])[CH2:16][N:28]1[CH2:27][CH2:26][N:25]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[O:18][CH3:17])[CH2:30][CH2:29]1

Participants

4

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 12961745HCID 12961745, compound

Product 1

HCID 12961751HCID 12961751, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7.3 g (0.033 mole) of 2,3-epoxypropoxy-2-(1,3,4-oxadiazol-2-yl)-benzene from Example VII and 6.4 g (0.033 mole) of 2-methoxy-phenylpiperazine in 50 ml of ethanol are refluxed for 17 hours. The solvent is stripped off on a rotary evaporator and the oily residue is taken up in methylene chloride. The solution is washed with 3×50 ml of water, dried over anhydrous sodium sulfate, filtered and concentrated. 12.6 g (93% of theory) of a pale yellow oil are obtained.

Workup

  1. customThe solvent is stripped off on a rotary evaporator
  2. washThe solution is washed with 3×50 ml of water
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. custom12.6 g (93% of theory) of a pale yellow oil are obtained

Sources & evidence

ORD record
ord-470fcc4c4f994e69a2cc0b9ead3bbe57
Source dataset
uspto-grants-1982_10
Patent number
US04353904

Reaction notes

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