反应详情

3.0 g 4-[4-Butyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-2-chloro-benzaldehyde were dissolved in 100 ml methanol and 300 mg sodium borohydride were added. The reaction mixture was stirred at room temperature for two hours, then the solvent was removed in vacuo and the residue dissolved in 100 ml ethyl acetate. This solution was washed three times with 30 ml brine, dried over MgSO4 and the solvent was removed in vacuo to provide 3.0 g {4-[4-Butyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-2-chloro-phenyl}-methanol as pale yellow solid.

1. customthe solvent was removed in vacuo
2. dissolutionthe residue dissolved in 100 ml ethyl acetate
3. washThis solution was washed three times with 30 ml brine
4. dry with materialdried over MgSO4
5. customthe solvent was removed in vacuo