Triethylamine → HCID 178441582, compound

Participants

Reaction Conditions

Reaction Steps

2.2 g {4-[4-Butyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-2-chloro-phenyl}-acetonitrile were dissolved in a mixture of 6 ml tetrahydrofuran and 12 ml methanol. 3.3 g hydroxylamine hydrochloride were added followed by the addition of 6.6 ml triethylamine. The reaction mixture was stirred at 60° C. for two hours. The solvents were removed in vacuo and the resulting residue poured into water and extracted five times with portions of 30 ml ethylacetate. The combined organic extracts were dried over MgSO4 and the solvent was evaporated in vacuo to provide 2.3 g 2-{4-[4-Butyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-2-chloro-phenyl}-N-hydroxy-acetamidine as crude material.

Provenance & Evidence