Ethyl Acetate → HCID 59296202, compound

Participants

Reaction Conditions

Reaction Steps

280 mg 2-Fluoro-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-ylmethoxy]-benzonitrile (intermediate example 1) were dissolved in 10 ml methanol. 390 mg sodium methoxide were added and the reaction mixture stirred at a temperature of 60° C. for two hours. The cooled reaction mixture was diluted by adding 200 ml ethyl acetate and washed three times with portions of 50 ml water. The organic layer was dried over MgSO4 and the solvent removed in vacuo to provide 140 mg 2-Methoxy-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzonitrile as pale yellow solid.

Provenance & Evidence