HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 9-[2-(1,4-Benzodioxan-2-yl)ethyl]-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 9-[2-(1,4-Benzodioxan-2-yl)ethyl]-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride salt | HCID 20522116 | — |
| Solvent | Water | HCID 962 | — |
| Product | 9-[2-(1,4-Benzodioxan-2-yl)ethyl]-1-oxa-4,9-diazaspiro[5.5]undecan-3-one | HCID 13059436 | 95.1% |
Reaction Steps
A solution of 3.5 g of 9-[2-(1,4-benzodioxan-2-yl)ethyl]-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride salt in water (50 ml) was adjusted to pH 12 with ammonium hydroxide solution and extracted with methylene chloride. The methylene chloride was evaporated to afford 3 g of 9-[2-(1,4-benzodioxan-2-yl)ethyl]-1-oxa-4,9-diazaspiro-[5.5]undecan-3-one as the free base, mp 139°-140° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04353901 |
| Source dataset | uspto-grants-1982_10 |
| ORD ID | ord-19ed51f29bce4adfb58d446bdfef0647 |
| Source note | uspto-grants-1982_10 |